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上?？泼羯镤N售CDCP1 (D8M5K) Rabbit mAb #12327 Cell Signaling，CST原裝品質，*，訂購CDCP1 (D8M5K) Rabbit mAb #12327 Cell Signaling，詳情請咨詢銷售人員！
產品詳細參數如下>>>>

產品名稱：CDCP1 (D8M5K) Rabbit mAb #12327 Cell Signaling
貨號：12327
品牌：CST(cell signaling)
抗體來源：Rabbit
克隆類型：Monoclonal
規(guī)格：

抗體應用：

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on * sequence homology.
特異性/敏感度：CDCP1 (D8M5K) Rabbit mAb recognizes endogenous levels of total CDCP1 protein. This antibody recognizes an epitope in the extracellular domain of CDCP1.
來源及純化方法：Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala354 of human CDCP1 protein.
抗體背景：

CDCP1 (CUB domain containing protein, SIMA135) is a putative stem cell marker that has been shown in research studies to be highly expressed in some human cancer cells and in both typical and atypical (cancerous) colons (1). Expression of CDCP1 may be epigenetically regulated, as methylation of promoter CpG sequences results in decreased CDCP1 expression (2). The corresponding CDCP1 gene encodes a glycoprotein that acts as a complex, multidomain transmembrane antigen. Three CUB domains in its extracellular region are possibly involved in cell adhesion or extracellular matrix interaction (1,3). Src-family kinases may phosphorylate CDCP1 at five tyrosine residues within its cytoplasmic domain to provide a potential binding site for SH2 domain-containing proteins (3). CDCP1 is a putative marker for hematopoietic stem cells (4,5).

關鍵詞：CST，抗體，一抗{byao_back}{byao_back2}

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